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| | ARTICLE | Am. J. innov. res. appl. sci. Volume 11, Issue-6, Pages 151-155 (December 2020) |
| Research Article 3 |
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| DECEMBER | VOLUME 11 | N° 6 | 2020 |
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American Journal of Innovative Research & Applied Sciences
Authors Contact
*Correspondant author and authors Copyright © 2020:
| Sanaa Sabour Alaoui | and | Amine Bennouri |
Affiliation.
1. Laboratory of Biotechnology & Sustainable | Development of Natural Resources | Polydisciplinary faculty of Beni Mellal | University Sultan Moulay Sliman | Beni Mellal | Morocco|
2. University Sultan Moulay Sliman | Beni Mellal | Morocco |
This article is made freely available as part of this journal's Open Access: ID | Sabour–Ref22-ajira051220 |
*Correspondant author and authors Copyright © 2020:
| Sanaa Sabour Alaoui | and | Amine Bennouri |
Affiliation.
1. Laboratory of Biotechnology & Sustainable | Development of Natural Resources | Polydisciplinary faculty of Beni Mellal | University Sultan Moulay Sliman | Beni Mellal | Morocco|
2. University Sultan Moulay Sliman | Beni Mellal | Morocco |
This article is made freely available as part of this journal's Open Access: ID | Sabour–Ref22-ajira051220 |
ABSTRACT
The world is currently in an open battle with an invisible virus of high gravity over the dynamics of life. This study is focused on the description of the structure of SARS CoV2 and on the receptors which play an intermediary role in the viral entry mechanism: TMPRSS2 which activates the ACE2 in order to facilitate the penetration of SARS CoV2 into the cell. The expression of genes encoding transmembrane receptors and its relationship to epigenetic markers including methylation was investigated. The impact of these epigenetic factors on the immune system suggest that the variability of SARS CoV2 is mainly due to environmental, nutritional and age factors which involve forces on our genes via these epigenetic markers. This explains why the variety of the basic viral reproduction rate Ro from one area to another is associated with epigenetic factors including methylation. The level of expression of ACE2 and TMPRSS2 may directly influences the level of severity of infection due to SARS CoV2. Analysis of the studies allowed us to suggest therapeutic targets that may participate in blocking viral spread via the development of specific and pharmacological DNAMT: DNA methyl transferases and may reduce the expression of genes allowing viral penetration and DNAMTs that strongly inhibit SARS CoV2 replication upon viral penetration. It is also suggested that androgen inhibitors represent an effective treatment against SARS CoV2.
Keywords: SARS CoV2, ACE2, TMPRSS2, angiotensin II, methylation
The world is currently in an open battle with an invisible virus of high gravity over the dynamics of life. This study is focused on the description of the structure of SARS CoV2 and on the receptors which play an intermediary role in the viral entry mechanism: TMPRSS2 which activates the ACE2 in order to facilitate the penetration of SARS CoV2 into the cell. The expression of genes encoding transmembrane receptors and its relationship to epigenetic markers including methylation was investigated. The impact of these epigenetic factors on the immune system suggest that the variability of SARS CoV2 is mainly due to environmental, nutritional and age factors which involve forces on our genes via these epigenetic markers. This explains why the variety of the basic viral reproduction rate Ro from one area to another is associated with epigenetic factors including methylation. The level of expression of ACE2 and TMPRSS2 may directly influences the level of severity of infection due to SARS CoV2. Analysis of the studies allowed us to suggest therapeutic targets that may participate in blocking viral spread via the development of specific and pharmacological DNAMT: DNA methyl transferases and may reduce the expression of genes allowing viral penetration and DNAMTs that strongly inhibit SARS CoV2 replication upon viral penetration. It is also suggested that androgen inhibitors represent an effective treatment against SARS CoV2.
Keywords: SARS CoV2, ACE2, TMPRSS2, angiotensin II, methylation
Corresponding author Author and Copyright Author © 2020: | Sanaa Sabour Alaoui * |. All Rights Reserved. All articles published in American Journal of Innovative Research and Applied Sciences are the property of
Atlantic Center Research Sciences, and is protected by copyright laws CC-BY. See: http://creativecommons.org/licenses/by-nc/4.0/
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American Journal of innovative
Research & Applied Sciences
Research & Applied Sciences
ISSN 2429-5396 (Online)
OCLC Number: 920041286
OCLC Number: 920041286
THE RELATIONSHIP BETWEEN EXPRESSION OF TMPRSS2 AND ANGIOTENSIN II AND PATHOGENICITY OF PEOPLE CAUSED BY THE INFECTION OF SARS CoV2
| Sanaa Sabour Alaoui | and | Amine Bennouri |. Am. J. innov. res. appl. sci. 2020; 11(6):151-155.
| PDF FULL TEXT | | XML FILE | | Received | October 05, 2020 | | Accepted | November 07, 2020 | | Published | December 13, 2020 |
| Sanaa Sabour Alaoui | and | Amine Bennouri |. Am. J. innov. res. appl. sci. 2020; 11(6):151-155.
| PDF FULL TEXT | | XML FILE | | Received | October 05, 2020 | | Accepted | November 07, 2020 | | Published | December 13, 2020 |