GENERAL INFORMATION
| | ARTICLE | Am. J. innov. res. appl. sci. Volume 14, Issue 5, Pages 253-259 (May, 2022) |
| Research Article 8 |
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| Info-AJIRAS-® Journal ISSN 2429-5396 (Online) / Reference CIF/15/0289M |
American Journal of Innovative Research & Applied Sciences
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American Journal of innovative
Research & Applied Sciences
Research & Applied Sciences
ISSN 2429-5396 (Online)
OCLC Number: 920041286
OCLC Number: 920041286
Authors Contact
*Correspondant author and authors Copyright © 2022:
| Jacquelin Albert Razanakoto 1,4* | Julio Hervé Andriamadio 1 | Olivier Rakotoarison2 |
Clément Lehimena 1 | Anne Wadouachi 3 | Amélie Raharisololalao 4 | and | Léa Herilala Rasoanaivo 4 |
Affiliation.
1. University of Antsiranana | Chemistry department | Faculty of Sciences | Antsiranana 201 | Madagascar |
2. University of Antananarivo | Laboratoire de Pharmacodynamie | Faculty of Sciences | Madagascar |
3. University of Picardie | Laboratoire LG2A | FRE CNRS 3517 | Amiens | France |
4. University of Antananarivo | Laboratoire LCSN/COB| Faculty of Sciences | Antananarivo 101|
This article is made freely available as part of this journal's Open Access: ID | jacquelin-Ref09-ajira120522 |
| MAY | VOLUME 14 | ISSUE N° 5 | 2022 |
ABSTRACT
Background: Psorospermum cerasifolium Baker is a small tree endemic of Madagascar. There leaves are used in traditional medicine for the treatment of diseases related to jaundice, wound and mycosis. Aim of the study: This work aims to evaluate the chemical constituents and antioxidant activity of this plant. Materials and methods: The chemical constituents of the hexane and ethyl acetate extracts of the leaves were studied. Column chromatography and TLC methods allow the isolation of products. The structures of the isolated products were identified by concerted analysis of the 1D and 2D NMR spectra and by comparison with the literatures. The antioxidant activity of the crude ethanolic extract and hexane, ethyl acetate and methanol extracts was evaluated using DPPH° free radical scavenging. Results: According to this method, Psorospermum cerasifolium AcOEt extract ensure trapping the DPPH at 88.09 %. The value is around 531.25 mM / mg / l of extract as equivalent to α-tocopherol with the concentration of 0.5 mg / ml. The fractionation of the hexane and ethyl acetate extracts led to the isolation of five known pentacyclic triterpene lupeol 1, taraxerol 2, 2-hydroxylupeol 7, acetyl aleuritolic acid 8, putranjivic acid 9 and four phenolic compounds with one new bisphenol 2,2’-di(benzenecarboxylic) 3, and three known compounds eriodictyol 4, 4’,7-dihydroxy-5,8-dimethoxyflavone 5 and β,2,3’,4,4’,6-hexahydroxy-α-(α-L-rhamnopyranosyl)dihydrochalcone 6.
Keywords: chalconglycoside/ flavonoids/ bisphenol/triterpenes/ antioxidant / Psorospermum cerasifolium / NMR.
Background: Psorospermum cerasifolium Baker is a small tree endemic of Madagascar. There leaves are used in traditional medicine for the treatment of diseases related to jaundice, wound and mycosis. Aim of the study: This work aims to evaluate the chemical constituents and antioxidant activity of this plant. Materials and methods: The chemical constituents of the hexane and ethyl acetate extracts of the leaves were studied. Column chromatography and TLC methods allow the isolation of products. The structures of the isolated products were identified by concerted analysis of the 1D and 2D NMR spectra and by comparison with the literatures. The antioxidant activity of the crude ethanolic extract and hexane, ethyl acetate and methanol extracts was evaluated using DPPH° free radical scavenging. Results: According to this method, Psorospermum cerasifolium AcOEt extract ensure trapping the DPPH at 88.09 %. The value is around 531.25 mM / mg / l of extract as equivalent to α-tocopherol with the concentration of 0.5 mg / ml. The fractionation of the hexane and ethyl acetate extracts led to the isolation of five known pentacyclic triterpene lupeol 1, taraxerol 2, 2-hydroxylupeol 7, acetyl aleuritolic acid 8, putranjivic acid 9 and four phenolic compounds with one new bisphenol 2,2’-di(benzenecarboxylic) 3, and three known compounds eriodictyol 4, 4’,7-dihydroxy-5,8-dimethoxyflavone 5 and β,2,3’,4,4’,6-hexahydroxy-α-(α-L-rhamnopyranosyl)dihydrochalcone 6.
Keywords: chalconglycoside/ flavonoids/ bisphenol/triterpenes/ antioxidant / Psorospermum cerasifolium / NMR.
PHYTOCHEMICAL AND ANTIOXIDANT EVALUATIONS OF Psorospermum cerasifolium Baker Hypericaceae
|Jacquelin Albert Razanakoto 1,4* | Julio Hervé Andriamadio 1 | Olivier Rakotoarison2 |Clément Lehimena 1 | Anne Wadouachi 3 | Amélie Raharisololalao 4 | and | Léa Herilala Rasoanaivo 4 ||. Am. J. innov. res. appl. sci. 2022; 14(5):253-259.
| PDF FULL TEXT | | Abstract and Author Contact | | XML FILE |
|Jacquelin Albert Razanakoto 1,4* | Julio Hervé Andriamadio 1 | Olivier Rakotoarison2 |Clément Lehimena 1 | Anne Wadouachi 3 | Amélie Raharisololalao 4 | and | Léa Herilala Rasoanaivo 4 ||. Am. J. innov. res. appl. sci. 2022; 14(5):253-259.
| PDF FULL TEXT | | Abstract and Author Contact | | XML FILE |
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